PKD is associated with the following conditions:
Aortic aneurysms
Brain aneurysms
Cysts in the liver, pancreas, and testes
Diverticula of the colon
As many as half of people with PKD have cysts on the liver. A family history of PKD increases your risk for the condition.
The pathogenesis of PKD is still unknown, but both ADPKD and ARPKD are associated with abnormalities in the proteins involved in the development of functional, sensory cilia in the kidneys; these protein abnormalities are responsible for the disruption of intracellular calcium regulation by cyclic adenosine monophosphate stimulation, leading to abnormal proliferation of tubular epithelial cells and formation of benign cysts
Risk factors:
Parental consanguinity
Presence of hepatic fibrosis
Siblings with PKD
Aortic aneurysms
Brain aneurysms
Cysts in the liver, pancreas, and testes
Diverticula of the colon
As many as half of people with PKD have cysts on the liver. A family history of PKD increases your risk for the condition.
The pathogenesis of PKD is still unknown, but both ADPKD and ARPKD are associated with abnormalities in the proteins involved in the development of functional, sensory cilia in the kidneys; these protein abnormalities are responsible for the disruption of intracellular calcium regulation by cyclic adenosine monophosphate stimulation, leading to abnormal proliferation of tubular epithelial cells and formation of benign cysts
Risk factors:
Parental consanguinity
Presence of hepatic fibrosis
Siblings with PKD
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